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Chapter 20: Endocrinology
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Notes on Medicine
Chapter 20: Endocrinology
Congenital Adrenal Hyperplasia (CAH)
Congenital Adrenal Hyperplasia (CAH)
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Date
13 Jan, 2025
Congenital Adrenal Hyperplasia (CAH) autosomal recessive traits. The most common enzyme defect is 21-hydroxylase deficiency. 11β-hydroxylase & 17-hydroxylasedeficiency → hypertension
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PheochromocytomaÂ
PheochromocytomaÂ
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Date
13 Jan, 2025
Pheochromocytoma 80% of NETs occur in the adrenal medulla (pheochromocytomas), 20% arise elsewhere in the body in sympathetic ganglia
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Primary hyperaldosteronism
Primary hyperaldosteronism
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Date
13 Jan, 2025
Primary hyperaldosteronism Indications to test for mineralocorticoid excess in hypertensive patients include Hypokalaemia (including hypokalemia induced by thiazide diuretics), Poor
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Adrenal insufficiencyÂ
Adrenal insufficiencyÂ
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Date
13 Jan, 2025
Adrenal insufficiency Clinical features: weight loss, hyponatraemia, hypotension → shock, hypoglycemia, hypercalcemia. anorexia, nausea, vomiting, diarrhea, muscle cramps vitiligo
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Steroid withdrawal or tapering
Steroid withdrawal or tapering
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Date
13 Jan, 2025
Steroid withdrawal or tapering Indication of steroid therapy Endocrine: replacement therapy, Graves ophthalmopathy SKIN: Dermatitis, Pemphigus Hematologic: Leukemia, lymphoma,
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Cushing SyndromeÂ
Cushing SyndromeÂ
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Date
13 Jan, 2025
Cushing Syndrome Clinical features Fat deposition Obesity: Weight gain is the commonest symptom & thus obesity commonest sign
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Pseudohypoparathyroidism
Pseudohypoparathyroidism
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Date
13 Jan, 2025
Pseudohypoparathyroidism Imprinting disorders (PAP) Pseudohypoparathyroidism Angelman syndrome (AS) Prader–Willi syndrome Pathology: tissue resistance to the effects of PTHÂ
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Hyperparathyroidism
Hyperparathyroidism
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Date
13 Jan, 2025
Hyperparathyroidism Primary It is caused by autonomus secretion of PTH from adenoma, carcinoma or hyperplasia of parathyroid gland
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Hyperprolactinemia
Hyperprolactinemia
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Date
13 Jan, 2025
Hyperprolactinemia SAQ. A 20 year old female presented with bilateral nipple discharge and amenorrhea for 3 months. Mention
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