Rhabdomyolysis

Causes:

• Lime or muscle compartment ischaemic for a prolonged period. 
• trauma and crush injury
• after overexertion of muscles. 

• intense physical exercise 
• medical condition: malignant hyperpyrexia or neuroleptic malignant syndrome. 

Investigation: 

• Creatine kinase (CK) level of > 1000 U/L is highly suggestive, 

Management:

• Identification and correction of the underlying cause 
• support for multi-organ dysfunction

• forced alkaline diuresis (using intravenous bicarbonate infusion and furosemide) can be used to maintain a good flow of less acidic fluid within the renal tubules and reduce myoglobin precipitation