Hereditary angioedema 

SAQ. A 22 years old female developed stridor and facial swelling just after a dental intervention due to toothache. She had no previous history of atopy. Her mother also had a repeated history of this type of illness that usually resolves within a day.

1. Write down 3 differential diagnoses from this scenario

1. Hereditary angioedema
2. Allergic reaction to specific trigger
3. Idiopathic angioedema
4. ACE-inhibitor associated angioedema

1. Write down 2 specific tests to reach the diagnosis

• C4 levels: Low
• C1 inhibitor levels

Management

Patient education:

• Self-administer therapy 
• Carry a MedicAlert or similar.

SAQ. A 17-year-old boy complains of severe abdominal pain & breathlessness. He had H/O appendicectomy 6 months back due to similar type of pain. On exams, facial swelling & rash over extremities.

1. What’s your diagnosis? How will you treat him now? → Answer: Hereditary angioedema
2. How can you prevent further attacks?